Browsing by Author "Costales Cordero, Jaime Alfredo"

2b-RAD genotyping for population genomic studies of Chagas disease vectors: Rhodnius ecuadoriensis in Ecuador

Costales Cordero, Jaime Alfredo; Ocaña Mayorga, Sofía Beatriz; Villacis Salazar, Anita Gabriela; Yumiseva Marín, César Alberto (2017)

Rhodnius ecuadoriensis is the main triatomine vector of Chagas disease, American trypanosomiasis, in Southern Ecuador and Northern Peru. Genomic approaches and next generation sequencing technologies have become powerful ...

A Soluble Factor from Trypanosoma cruzi Inhibits Transforming Growth Factor-ß-Induced MAP Kinase Activation and Gene Expression in Dermal Fibroblasts

Costales Cordero, Jaime Alfredo (2011)

The protozoan parasite Trypanosoma cruzi, which causes human Chagas´disease, exerts a variety of effects on host extracellular matrix (ECM) including proteolytic degradation of collagens and dampening of ECM gene expression. ...

Analytical validation of quantitative Real - Time PCR methods for quantification of trypanosoma cruzi DNA in blood samples from chagas disease patients

Costales Cordero, Jaime Alfredo (09/2015)

An international study was performed by 26 experienced PCR laboratories from 14 countries to assess the performance of duplex quantitative real-time PCR (qPCR) strategies on the basis of TaqMan probes for detection and ...

Cell invasion by trypanosoma cruzi and the type i interferon response

Costales Cordero, Jaime Alfredo (2017)

The life cycle of Trypanosoma cruzi is digenetic, comprising developmental stages in an invertebrate host (vector) as well as a mammalian host. Well over a 100 species of blood feeding triatomines may harbor T. cruzi, while ...

Chagas Disease Has Not Been Controlled in Ecuador

Costales Cordero, Jaime Alfredo (2016-06-28)

A recent study by Cartelle Gestal et al. reported an analysis of data from the Ministry of Public Health on the epidemiological situation of neglected tropical diseases in Ecuador. Based on a misleading definition of Chagas ...

Chagas disease reactivation in a heart transplant patient infected by domestic Trypanosoma cruzi discrete typing unit I (TcIDOM)

Costales Cordero, Jaime Alfredo (25/08/2015)

Background: Trypanosoma cruzi, causative agent of Chagas disease, displays high intraspecific genetic diversity: six genetic lineages or discrete typing units (DTUs) are currently recognized, termed TcI through TcVI. Each ...

Congenital Chagas Disease in the ecuadorian amazon: maternal screening at delivery and evaluation of risk factors associated with vector exposure

Costales Cordero, Jaime Alfredo (2019)

Congenital infection with Trypanosoma cruzi remains a major route for Chagas disease transmission in endemic and non-endemic regions. We evaluated an intervention strategy aimed to detect congenital Chagas disease cases ...

Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity

Costales Cordero, Jaime Alfredo; Ocaña Mayorga, Sofía Beatriz (2020-12-16)

Analysis of genetic polymorphism is a powerful tool for epidemiological surveillance and research. Powerful inference from pathogen genetic variation, however, is often restrained by limited access to representative target ...

Diversidad genética del gen del mini- exón en Trypanosoma cruzi y Trypanosoma rangeli en dos localidades de la provincia de Loja

Costales Cordero, Jaime Alfredo

El Centro de Investigación en Enfermedades Infecciosas y Crónicas (CIEIC) organiza el “IV Encuentro Internacional de Investigación en Enfermedades Infecciosas y Medicina Tropical”, del 13 al 15 de Junio, en la Pontificia ...

Factores sociales asociados con la utilización de los servicios de atención prenatal en Ecuador

Costales Cordero, Jaime Alfredo; Grijalva Cobo, Mario Javier (11/2016)

Objetivos: La atención prenatal es uno de los pilares de la salud pública y permite el acceso a intervenciones tales como la prevención de la transmisión materno-infantil del VIH y de la sífilis congénita. Este artículo ...

Fatal acute Chagas disease by Trypanosoma cruzi DTU TcI, Ecuador

Costales Cordero, Jaime Alfredo (2020-02)

Background: Chagas disease is caused by the haemoflagellate protozoan Trypanosoma cruzi. Currently, T. cruzi recognizes seven discrete typing units (DTUs): TcI to TcVI and Tcbat. The genetic diversity of T. cruzi is suspected ...

In vitro susceptibility of Trypanosoma cruzi discrete typing units (DTUs) to benznidazole: A systematic review and meta-analysis

Costales Cordero, Jaime Alfredo (2021-03)

Background: Chagas disease, a neglected tropical disease endemic to Latin America caused by the parasite Trypanosoma cruzi, currently affects 6–7 million people and is responsible for 12,500 deaths each year. No vaccine ...

Knowledge, attitudes, and practices towards covid-19 among ecuadorians during the outbreak: an online cross-sectional survey

Costales Cordero, Jaime Alfredo; Moncayo Benalcázar, Ana Lucía (2020-12)

Preventing the transmission of SARS-CoV-2 (causative agent for COVID-19) requires implementing contact and respiratory precautions. Modifying human behavior is challenging and requires understanding knowledge, attitudes, ...

Meiotic sex in Chagas disease parasite Trypanosoma cruzi

Costales Cordero, Jaime Alfredo (2019)

Genetic exchange enables parasites to rapidly transform disease phenotypes and exploit new host populations. Trypanosoma cruzi, the parasitic agent of Chagas disease and a public health concern throughout Latin America, ...

A national survey to determine prevalence of Trypanosoma cruzi infection among pregnant women in Ecuador

Costales Cordero, Jaime Alfredo; Yumiseva Marín, César Alberto (09/02/2015)

A nationwide survey was conducted to obtain an estimate of Chagas disease prevalence among pregnant women in Ecuador. As part of a national probability sample, 5,420 women seeking care for delivery or miscarriage at 15 ...

Perfiles proteómicos asociados a cepas de Trypanosoma cruzi DTU I de alta y baja infectividad in vitro

Costales Cordero, Jaime Alfredo

El Centro de Investigación en Enfermedades Infecciosas y Crónicas (CIEIC) organiza el “IV Encuentro Internacional de Investigación en Enfermedades Infecciosas y Medicina Tropical”, del 13 al 15 de Junio, en la Pontificia ...

Prediction and prevention of parasitic diseases using a landscape genomics framework

Costales Cordero, Jaime Alfredo; Grijalva Cobo, Mario Javier; Ocaña Mayorga, Sofía Beatriz (2017-04)

Substantial heterogeneity exists in the dispersal, distribution and transmission of parasitic species. Understanding and predicting how such features are governed by the ecological variation of landscape they inhabit is ...

Remarkable genetic diversity of Trypanosoma cruzi and Trypanosoma rangeli in two localities of southern Ecuador identified via deep sequencing of mini-exon gene amplicons

Costales Cordero, Jaime Alfredo (2020-05)

Trypanosoma cruzi, the causative agent of Chagas disease, and T. rangeli are kinetoplastid parasites endemic to Latin America. Although closely related to T. cruzi and capable of infecting humans, T. rangeli is non-pathogenic. ...

Repeat-driven generation of antigenic diversity in a major human pathogen, Trypanosoma cruzi

Costales Cordero, Jaime Alfredo; Ocaña Mayorga, Sofía Beatriz (2021-03)

Trypanosoma cruzi, a zoonotic kinetoplastid protozoan parasite, is the causative agent of American trypanosomiasis (Chagas disease). Having a very plastic, repetitive and complex genome, the parasite displays a highly ...

Sex, subdivision, and domestic dispersal of Trypanosoma Cruzi Lineage I in southern Ecuador

Ocaña Mayorga, Sofía Beatriz; Costales Cordero, Jaime Alfredo; Grijalva Cobo, Mario Javier (2010)

Molecular epidemiology at the community level has an important role in zoonotic disease control programmes where genetic markers are suitably variable to unravel the dynamics of local transmission. We evaluated the molecular ...

Browsing by Author "Costales Cordero, Jaime Alfredo"

Browsing by Author "Costales Cordero, Jaime Alfredo"

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